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How Does Hyperbaric Oxygen Therapy Reduce Chronic Inflammation?

Patient receiving Hyperbaric Oxygen Therapy to help reduce chronic inflammation and support tissue healing

Inflammation is helpful when it is short-term and tied to an injury or infection. The problem starts when the immune system keeps firing even when the original trigger is gone or when there is no real threat at all. That ongoing state can damage healthy tissue and contribute to long-term health problems.

This is why people search for chronic inflammation treatment options that go beyond symptom relief. Hyperbaric medicine is one area drawing interest because HBOT delivers high levels of oxygen under pressure. It supports repair, circulation, and immune balance.

Today, Hyperbaric Oxygen Therapy (HBOT) for chronic inflammation is getting more attention because it may help calm the body’s inflammatory response while supporting healing. Let’s understand how it helps to treat chronic inflammation. 

What Is Chronic Inflammation?

Chronic inflammation is a long-lasting immune response that continues even when the body is not dealing with an active injury or infection. It can last for months or years and may come and go over time.

It is linked to a wide range of inflammatory conditions, including rheumatoid arthritis, lupus, psoriasis, Crohn’s disease, inflammatory bowel disease, asthma, COPD, heart disease, and type 2 diabetes. That is why many people do not recognize it right away.

Common Causes of Chronic Inflammation

The main sources of chronic inflammation include unresolved acute issues, autoimmune disorders, lifestyle factors, diet and toxins, and obesity. These triggers overlap, which is part of the reason the condition can be hard to pin down.

Unresolved acute issues

Sometimes an infection, injury, or tissue problem never fully settles. The immune response stays active, and that can keep inflammation going longer than it should.

Autoimmune disorders

In autoimmune conditions, the immune system attacks the body’s own tissue. Recent studies list lupus, rheumatoid arthritis, psoriasis, and ankylosing spondylitis among the conditions tied to chronic inflammation.

Lifestyle factors

Low physical activity, chronic stress, disrupted sleep, tobacco use, and too much alcohol all raise the risk of persistent inflammation. These factors can also slow recovery.

Diet and toxins

Regularly eating highly processed, high-salt, or trans-fat foods worsens inflammation. Exposure to toxins, hazardous waste, and industrial chemicals can also contribute.

Obesity

Having a BMI at or above 30, especially with excess visceral fat, is a common driver of chronic inflammation. Fat tissue behaves like an active inflammatory organ.

Symptoms Commonly Associated With Chronic Inflammation

Chronic inflammation can show up in vague ways, so people ignore it at first. Common symptoms include fatigue, joint pain, muscle aches, brain fog, digestive issues, and slow-healing wounds.

Fatigue

Persistent inflammation can leave you feeling drained even after rest. Fatigue and insomnia are also common chronic inflammation symptoms.

Joint pain

Inflammatory activity can settle in the joints and cause pain or stiffness. This is one reason conditions like rheumatoid arthritis feel so limiting.

Muscle aches

Aches and soreness can happen when inflammatory chemicals affect soft tissue. They may appear without a clear injury.

Brain fog

People describe this as poor focus, slower thinking, or memory problems. Chronic inflammation has been linked to mood disorders and neurodegenerative disease.

Digestive issues

Diarrhea, constipation, acid reflux, and other GI symptoms can all occur with ongoing inflammation. This is common in inflammatory bowel disease and related conditions.

Slow-healing wounds

Inflamed tissue often has poor circulation and poor repair capacity. That can delay healing and increase the risk of infection.

What Is HBOT?

Hyperbaric oxygen therapy, or HBOT, is a medical treatment where a person breathes 100% oxygen inside a chamber with pressure higher than normal air pressure. The FDA explains that this increased pressure helps the lungs collect more oxygen so more can reach the tissues that need it.

HBOT is an established treatment for certain FDA-cleared uses, including diabetic foot ulcers, severe wounds, radiation injury, carbon monoxide poisoning, and several other conditions. 

How HBOT works

HBOT works by increasing the amount of oxygen carried in the blood and delivered to damaged tissue. That extra oxygen may support healing in several ways.

Blood plasma saturation

Under pressure, more oxygen dissolves into blood plasma, not just red blood cells. This can help oxygen move where circulation is poor.

Reaching starved tissues

Inflamed or damaged tissue may not get enough oxygen through normal blood flow. HBOT helps deliver oxygen to these starved areas.

Reduced swelling

The pressure in the chamber causes vasoconstriction, which helps reduce swelling while still preserving oxygen delivery. Less swelling means less pressure on injured tissue.

New blood vessel growth

HBOT is linked to angiogenesis, or the growth of new blood vessels, which may improve long-term blood supply to healing tissue. Better circulation supports recovery.

Infection control and healing

The FDA says HBOT helps the body heal and fight certain infections. That matters because infection keeps inflammation active for longer.

How HBOT May Influence Inflammatory Processes

The link between HBOT and inflammation is one reason this therapy is being studied so closely. Research suggests it may influence inflammatory signaling, tissue oxygenation, and healing speed.

Improved tissue oxygenation

Inflamed tissue often becomes oxygen-starved. HBOT raises oxygen levels in those areas, which may help the tissue function better and recover faster.

Support for cellular repair

Oxygen is needed for collagen formation, wound repair, and normal cell activity. By improving oxygen supply, HBOT may support the body’s repair work during chronic inflammation.

Potential effects on inflammatory markers

Some studies report lower inflammatory markers after HBOT. One review found decreases in markers such as CRP and ESR in certain patient groups, and a published study reported a significant drop in suPAR after HBOT in people with low-grade chronic inflammation.

Enhanced circulation and recovery

By improving oxygen delivery and encouraging vessel growth, HBOT may support better blood flow over time. That can matter in wounds and other chronic inflammatory conditions where recovery is slow.

What does current research say?

Current HBOT research is promising, but it is not a cure-all. Studies found that hyperbaric oxygen reduced reactive oxygen species production in inflammatory neutrophils, suggesting a possible anti-inflammatory effect.

Other research and clinical reports have described improvements in inflammatory markers and symptoms in conditions such as rheumatoid arthritis, fibromyalgia, traumatic brain injury, and chronic inflammatory response syndrome. For example, one case study reported symptom improvement and reduced biomarkers after 40 low-pressure HBOT sessions.

That said, the FDA is clear that HBOT is only cleared for specific conditions, and it has not authorized chambers for general claims like curing cancer, autism, Lyme disease, or Alzheimer’s disease. So the most accurate way to view HBOT is as a medical tool with proven uses and still-growing evidence in other areas.

Who May Be a Candidate for HBOT?

People with non-healing wounds, diabetic foot ulcers, radiation injury, certain severe infections, compromised grafts or flaps, and other FDA-cleared conditions may be candidates for HBOT. Some clinics also discuss HBOT for inflammatory conditions, but those uses should be considered case by case with a licensed clinician.

A person with chronic inflammation may be evaluated if they have ongoing wounds, poor circulation, slow recovery, or symptoms tied to inflammatory disease. The right plan depends on diagnosis, medical history, and the treatment goal.

Get Advanced Wound Care at SAAK Health

If you live in Brookfield, SAAK Health offers advanced wound care using HBOT along with other advanced wound care treatments. This kind of care can be helpful for patients who need more than basic dressing changes. Our experts provide a customized treatment plan focused on healing, circulation, and infection control.

For wounds that are slow to close or complicated by poor oxygen delivery, SAAK Health combines hyperbaric medicine with wound-focused care to speed up recovery.

Conclusion

HBOT chronic inflammation helps by raising tissue oxygen, reducing swelling, supporting repair, and influencing some inflammatory pathways.

For people with inflammatory conditions, HBOT can be a useful part of care when it is used for the right reason and in the right setting. The key is to match the therapy to the condition and seek specialized care at SAAK Health.

FAQs

Can HBOT reduce inflammation?

Yes, HBOT may help reduce inflammation in some settings by improving oxygen delivery and affecting inflammatory signaling. Research is promising, but results vary by condition and treatment plan.

How many HBOT sessions are usually required?

The number of sessions depends on the condition being treated. Some studies and clinical protocols use 20 to 40 sessions, while certain wound and radiation cases may require more.

Is HBOT approved for inflammatory diseases?

No, HBOT is not broadly FDA-cleared for inflammatory diseases. It is cleared for specific conditions such as diabetic foot ulcers, radiation injury, severe infections, and other listed indications.

Are HBOT results permanent?

The results of HBOT are often long-lasting or even permanent, but their permanence heavily depends on the condition treated. Some people maintain benefits, but others may need ongoing treatment or repeat care depending on the underlying condition. Long-term results usually depend on whether the root cause is also being addressed.

Is HBOT safe?

HBOT is generally safe when used for FDA-cleared indications at accredited facilities, and serious complications are rare. Possible risks include ear or sinus pain, temporary vision changes, middle ear injury, and, rarely, lung collapse.

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Kristin Cuff

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saakhealth

18200 W Capitol Dr Suite 200,
Brookfield, WI 53045

  • [email protected]
  • 262.444.5148
  • 866.493.3523

For ASC

  • 262.444.5149
Our Services
  • Family Medicine
  • Wound Care Clinic
  • Ambulatory Surgery
  • Women's Center for Incontinence and Pelvic Health
  • Cardiology and Vascular Care
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